Tremella: The Beauty Mushroom That Nourishes Skin, Hormones and Gut Health
The beauty mushroom that enhances memory & cognition, with other bonus health impacts.
I am so excited to announce my new tea blends & medicinal mushrooms! The first two are favourites (a bit like choosing favourite children!), Tremella (Tremella fuciformis) and Lion's Mane (stay tuned for the upcoming blog post).
Learn why I think they are must-haves in almost any home dispensary!
While everyone's debating the latest collagen supplements and skincare trends, there's been a quieter revolution happening in the world of evidence-based natural medicine. Tremella fuciformis, a medicinal mushroom that's been treasured since the Tang Dynasty, is finally receiving the scientific recognition it deserves—and the research is nothing short of remarkable.
Known as "The Beauty Mushroom," Tremella offers far more than skin-deep benefits. Recent clinical studies reveal this translucent, jelly-like fungus can support everything from blood sugar regulation to cognitive function, making it particularly valuable for women navigating perimenopause, or anyone with metabolic concerns, digestive health issues and chronic inflammatory conditions.
This article covers:
• Ancient Beauty Secret Meets Modern Science: Tremella's traditional use for skin health is now backed by clinical research showing improved hydration, collagen production, and UV protection
• Metabolic Powerhouse: Clinical trials demonstrate significant improvements in HbA1c, waist circumference, cholesterol levels, and insulin sensitivity
• Gut-Skin Connection: Tremella's prebiotic properties support microbiome balance, reduce inflammation, and strengthen intestinal barrier function
• Hormonal Support for Women: Particularly valuable during perimenopause and menopause for addressing skin dryness, cognitive function, and inflammatory changes
• Multi-System Benefits: Research reveals neuroprotective, hepatoprotective, and immune-modulating properties with applications for various chronic conditions
Looks like a brain - and helps the brain!
The Science Behind Ancient Wisdom
In ancient China, Tremella was a staple in imperial courts, with Yang Guifei, one of history's most celebrated beauties, reportedly consuming Tremella soup daily. Her legendary complexion wasn't merely a coincidence—modern research has validated what Traditional Chinese Medicine practitioners have long understood about this remarkable mushroom.
What makes Tremella unique isn't just its gelatinous appearance, but its complex biochemical profile. The mushroom contains high levels of polysaccharides, particularly acid heteropolysaccharides rich in mannose, xylose, and glucuronic acid. These compounds work similarly to hyaluronic acid but with smaller molecular size, allowing for deeper tissue penetration and more sustained therapeutic effects.
Unlike most mushrooms, Tremella depends on a companion fungus (Annulohypoxylon spp.) to grow, creating a symbiotic relationship that produces its distinctive nutrient density and bioactive compounds. This unique cultivation process contributes to its impressive array of therapeutic properties: antioxidant, anti-inflammatory, hypoglycaemic, immunomodulatory, hepatoprotective, neuroprotective, and skin regenerative effects.
Skin Health and Anti-Ageing
Tremella's reputation as a beauty enhancer isn't just traditional wisdom—rigorous scientific research confirms its remarkable effects on skin health. Studies demonstrate that Tremella polysaccharides can increase skin moisture and elasticity whilst stimulating the production of collagen, elastin, and hyaluronic acid in dermal fibroblasts.
Research published in the Journal of Dermatological Science showed that Tremella extract significantly reduced UV-induced oxidative damage in human skin cells, whilst animal studies revealed decreased skin collagen loss after UV exposure alongside increased levels of type I collagen, elastin, and hyaluronic acid, all whilst reducing oxidative stress markers.
The mushroom's photoprotective properties extend beyond prevention. Clinical studies have shown that Tremella can enhance wound healing by promoting keratinocyte and fibroblast migration, reducing melanin production and tyrosinase activity (helping with hyperpigmentation), and decreasing the expression of matrix metalloproteinase-1 (MMP-1), an enzyme involved in wrinkle formation.
What's particularly impressive is Tremella's ability to work both internally and topically, supporting skin structure, barrier function, hydration, and repair through multiple pathways. This makes it a genuinely comprehensive approach to skin health that addresses both symptoms and underlying causes.
(Watch this space! I’m formulating topical creams and balms with my famous magnesium base!)
Metabolic Health:
Perhaps the most compelling recent research centres on Tremella's metabolic effects. A 2024 randomised, placebo-controlled clinical trial published in Clinical Nutrition found that daily Tremella extract consumption significantly reduced waist circumference and HbA1c levels in overweight, prediabetic adults over 12 weeks, with no adverse effects reported.
The metabolic benefits extend well beyond blood sugar regulation. Multiple studies have demonstrated Tremella's ability to:
Lower fasting glucose, insulin, and HbA1c levels
Reduces total cholesterol, triglycerides, and LDL whilst increasing HDL
Inhibits fat absorption and suppresses fat cell formation
Modulate gene expression associated with insulin sensitivity and fat metabolism
Supports healthy weight management through multiple pathways
The mechanisms behind these effects are particularly sophisticated. Tremella activates the insulin-signalling PI3K/Akt pathway, downregulates adipogenesis-related genes including PPAR-γ and leptin, and modulates the gut microbiome to improve short-chain fatty acid production, creating a comprehensive approach to metabolic health that addresses multiple contributing factors simultaneously.
The Gut-Health Connection
Tremella's therapeutic effects extend significantly into gastrointestinal health, where its polysaccharides function as powerful prebiotics. The mushroom has been shown to nourish beneficial bacteria whilst supporting gut barrier integrity through multiple mechanisms.
Clinical research demonstrates that Tremella can increase expression of tight junction proteins (including ZO-1 and occludin), effectively restoring gut permeability and addressing "leaky gut" syndrome. Simultaneously, it upregulates mucin production for enhanced mucosal defence and reduces inflammatory markers in models of ulcerative colitis and inflammatory bowel disease.
The microbiome benefits are particularly noteworthy. Studies show Tremella supplementation can lower populations of pathogenic bacteria such as Proteobacteria and Escherichia-Shigella whilst increasing beneficial SCFA-producing species including Lactobacillus, Alistipes, and Muribaculaceae. This microbiome modulation creates cascading benefits for immune function, metabolic health, and inflammatory regulation throughout the body.
If you are experiencing IBS, IBD, or intestinal hyperpermeability (aka Leaky Gut), Tremella offers a gentle yet effective therapeutic addition, addressing both symptoms and underlying microbial imbalances.
Liver Support and NAFLD Management
Tremella's liver protective properties make it particularly valuable for addressing non-alcoholic fatty liver disease (NAFLD) and related metabolic conditions (Type II diabetes, pre-diabetes, PCOS, obesity, glyphosate/AMPK exposure). Preclinical studies demonstrate that Tremella supplementation can reduce liver fat accumulation, normalise liver enzyme levels (ALT and AST), and suppress inflammatory cytokines including TNF-α, IL-6, and IL-1β.
The mushroom also improves antioxidant enzyme activity whilst regulating some key regulators of liver metabolism. Meaning Tremella is a promising tool in the natural management of fatty liver disease, particularly when combined with dietary and lifestyle interventions.
Immune Modulation & Inflammation Regulation
Like many medicinal mushrooms, Tremella contains β-glucans that activate immune cells through receptors in the gut lining. However, its immunomodulatory effects are particularly sophisticated, demonstrating the ability to enhance immune function when needed whilst dampening excessive inflammatory responses.
Preclinical studies reveal that Tremella can polarise tumour-associated macrophages from the immunosuppressive M2 state to the proinflammatory, anticancer M1 state, promote dendritic cell maturation and T cell infiltration in tumours, and modulate the tumour microenvironment to support immune surveillance. These findings suggest potential applications as supportive adjunct therapy in cancer care, particularly for immune recovery following conventional treatments. Always speak to an oncologist first to ensure Tremella is appropriate and safe in your case.
The mushroom's anti-inflammatory effects extend to various conditions, including gout, atopic dermatitis, and inflammatory bowel disease. Key pathways influenced include NF-κB and MAPK (involved in chronic inflammation) and Nrf2 (which activates antioxidant defence systems), creating comprehensive inflammatory modulation that benefits multiple body systems.
Cognitive Support and Neuroprotection
Emerging research reveals Tremella's neuroprotective properties, showing promise for memory support and protection against age-related cognitive decline. The mushroom's antioxidant polysaccharides help guard against neuroinflammation whilst enhancing nerve regeneration and supporting mitochondrial function in brain tissue.
For women experiencing perimenopausal brain fog, often caused by neuroinflammation, fluctuating hormones, and oxidative stress, Tremella offers targeted support through multiple mechanisms. Studies suggest it can enhance memory and learning through antioxidant action, support neurogenesis and nerve growth, reduce neuroinflammation linked to hormonal transitions, and protect against age-related cognitive decline.
Perimenopause & Menopause
The hormonal shifts of perimenopause and menopause create particular challenges: vaginal dryness, sleep disruption, cognitive changes, and skin thinning as oestrogen levels decline. Tremella's unique properties make it exceptionally well-suited for supporting women through these transitions.
The mushroom's mucopolysaccharides help address systemic dryness, a common concern during menopause that affects skin, mucous membranes, and joint health. Research suggests Tremella may help improve vaginal mucosa hydration, support skin integrity and elasticity, and reduce inflammatory cytokines associated with hormonal decline.
For sleep and mood support, Tremella's antioxidant and adaptogenic properties support nervous system balance and may help reduce night sweats and irritability. When combined with complementary herbs like Shatavari and Rehmannia, it creates comprehensive hormonal support that addresses multiple symptoms simultaneously.
Nutritional Profile
Beyond its therapeutic polysaccharides, Tremella is naturally nutrient-dense, containing ergosterol (a precursor to vitamin D2), B-vitamins including B1, B2, B6, and folate, essential minerals like zinc, calcium, magnesium, iron, and copper, plus soluble fibre and prebiotic compounds.
Particularly noteworthy is Tremella's ability to accumulate high levels of vitamin D2 when exposed to UV light, potentially offering additional benefits for clients with limited sun exposure or vitamin D deficiency, common concerns for women during hormonal transitions.
Dosing
Tremella's gentle, neutral thermal nature makes it suitable for a broad range of clinical presentations. It's particularly valuable for addressing skin dryness, eczema, or photoageing, prediabetes, insulin resistance, or metabolic syndrome, fatty liver or elevated lipids, chronic immune dysregulation, gut permeability or microbiome imbalances, and as adjuvant support in various chronic conditions.
Typical dosing includes:
Powdered extract: 0.5-1 g daily, added to your morning hot beverage, or make your own beverage from it!
Culinary preparation: Soaked and simmered in soups or desserts
Topical applications: In creams for barrier support and pigmentation concerns
Enhanced Benefits by combining
Tremella pairs exceptionally well with flavonoid-rich herbs like green tea, pomegranate, turmeric, rosella and hawthorn for amplified metabolic and antioxidant benefits. For women's health applications, it combines beautifully with Reishi, Shatavari, and Licorice for comprehensive hormonal support.
In metabolic protocols, combining Tremella with herbs that support insulin sensitivity and lipid metabolism creates synergistic effects. For skin health, pairing it with vitamin C, zinc, and omega-3 fatty acids enhances its collagen-supporting properties.
Safety and Contraindications
Tremella is generally well-tolerated with an excellent safety profile. However, certain individuals should exercise caution. Those with digestive weakness, characterised by bloating, loose stools, or sluggish digestion, may find Tremella's mucilaginous properties initially challenging.
Use caution if taking immunosuppressant medications or anticoagulants, and always work with a qualified practitioner when incorporating Tremella into complex treatment protocols, pharmaceutical medications or when managing serious health conditions.
Final Thoughts
Tremella fuciformis may appear unremarkable—like a translucent, jelly-like snowflake—but this humble mushroom represents a remarkable convergence of ancient wisdom and modern science. With clinical evidence supporting its effects on skin health, metabolic function, immune balance, gut integrity, and hormonal transitions, Tremella deserves serious consideration.
Whether I’m supporting clients through perimenopausal changes, addressing metabolic concerns, managing inflammatory conditions, or simply seeking to optimise skin health and healthy ageing, Tremella offers an evidence-based, well-tolerated option that works through multiple pathways to support optimal wellness.
Remember that all natural medicines achieve their best results when used thoughtfully - in naturopathy, I’m always treating the patient in front of me, not a disease or condition. What is right for one person may not be right for you. For optimal outcomes, work with a qualified practitioner who understands both traditional applications and current research to create a personalised protocol that addresses your specific health goals and circumstances.
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Cheng, Y., et al. (2022). Antioxidant activity of Tremella polysaccharides in UVA-damaged fibroblasts. Journal of Dermatological Science, 105(2), 151–159.
Chen, X., et al. (2023). Prebiotic effects of Tremella-derived polysaccharides. Molecules, 28(4), 1269.
Hou, J., et al. (2022). Photoprotective effects of Tremella polysaccharides in UV-radiated rat models. Phytotherapy Research, 36(5), 2332–2344.
Lee, S., et al. (2022). Wound healing effects of Tremella fuciformis extract. International Journal of Molecular Sciences, 23(8), 4421.
Li, T., et al. (2023). Tremella polysaccharides suppress adipogenesis via PPAR-γ and C/EBP-α downregulation. Journal of Ethnopharmacology, 287, 114925.
Li, W., et al. (2022). Anti-inflammatory effects of Tremella in colitis models. Inflammopharmacology, 30(4), 1289–1301.
Lin, X., et al. (2023). Macrophage polarisation and TNF signalling in Tremella-treated melanoma models. International Journal of Molecular Sciences, 24(7), 3478.
Lu, Z., et al. (2022). Tumour microenvironment modulation by Tremella polysaccharides. Cancer Immunology Research, 10(4), 224–234.
OptimalRx. (2024). Tremella fuciformis Technical Sheet. OptimalRx Pty Ltd.
Sun, L., et al. (2024). Tremella fuciformis improves HbA1c and waist circumference in overweight prediabetics: A randomised controlled trial. Clinical Nutrition, 43(1), 50–59.
Wang, K., et al. (2021). Tremella modulates gut microbiota and SCFA production in NAFLD mice. Gut Microbes, 13(1), 1939256.
Yang, M., et al. (2020). Tremella activates immune response in murine colitis model. Immunopharmacology and Immunotoxicology, 42(6), 460–471.
Zhang, L., et al. (2023). Neuroprotective mechanisms of Tremella polysaccharides. Phytomedicine, 108, 154512.
Zhao, Y., et al. (2020). Hypolipidaemic effects of Tremella on high-fat-fed rats. Food & Function, 11(3), 1897–1908.
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All medicines have actions, which means there can be reactions. In addition, you may be taking medications that will interact with a variety of naturally occurring substances, including natural herbs, supplements, vitamins, minerals or foods.
This is not medical advice and is not specific to your particular health circumstances. For the best results and to keep you safe, seek the assistance of a health of a trained practitioner and your doctor.
